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Comparative Study
, 83 (15), 5597-601

Products of Two Common Alleles at the Locus for Human Placental Alkaline Phosphatase Differ by Seven Amino Acids

Comparative Study

Products of Two Common Alleles at the Locus for Human Placental Alkaline Phosphatase Differ by Seven Amino Acids

P S Henthorn et al. Proc Natl Acad Sci U S A.

Abstract

Amino-terminal amino acid sequences (42 residues) were determined for the products of the three common alleles at the human placental alkaline phosphatase [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] gene locus. The sequences differ at position 3, which is proline in types 1 and 2 but is leucine in type 3. cDNA libraries were constructed in phage lambda gt11 and used to isolate clones covering the coding regions of types 1 and 3 cDNAs. Comparison of the deduced amino acid sequences of the types 1 and 3 proteins showed 7 differences out of 513 amino acids, each due to a single base substitution. cDNA sequence comparisons showed three silent substitutions in the coding regions and three base differences in the greater than 1 kilobase pairs of 3' untranslated sequences.

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