Metabolism of doxorubicin and epirubicin in adult human hepatocytes in culture

Pharmacol Res Commun. 1986 Apr;18(4):343-7. doi: 10.1016/0031-6989(86)90087-1.

Abstract

Epirubicin is the only anthracycline to be metabolized in humans through a glucuronidation pathway which is not observed in laboratory animals. In search of a model for the experimental study of this metabolism, we have observed that human hepatocytes in culture exhibited this pathway and could be of interest for the understanding of the metabolism of this new drug.

MeSH terms

  • Cells, Cultured
  • Doxorubicin / metabolism*
  • Epirubicin
  • Female
  • Glucuronates / metabolism
  • Humans
  • Liver / cytology
  • Liver / metabolism*
  • Middle Aged

Substances

  • Glucuronates
  • Epirubicin
  • Doxorubicin