A self-learned decomposition and classification model for schizophrenia diagnosis

Abstract

Background: Schizophrenia (SZ) is a type of neurological disorder that is diagnosed by professional psychiatrists based on interviews and manual screening of patients. The procedures are time-consuming, burdensome, and prone to human error. This urgently necessitates the development of an effective and precise computer-aided design for the detection of SZ. One such efficient source for SZ detection is the electroencephalogram (EEG) signals. Because EEG signals are non-stationary, it is challenging to find representative information in its raw form. Decomposing the signals into multi-modes can provide detailed insight information from it. But the choice of uniform decomposition and hyper-parameters leads to information loss affecting system performance drastically.

Method: In this paper, automatic signal decomposition and classification methods are proposed for the detection of SZ and healthy control EEG signals. The Fisher score method is used for the selection of the most discriminant channel. Flexible tunable Q wavelet transform (F-TQWT) is developed for efficient decomposition of EEG signals by reducing root mean square error with grey wolf optimization (GWO) algorithm. Five features are extracted from the adaptively generated subbands and selected by the Kruskal Wallis test. The feature matrix is given as an input to the flexible least square support vector machine (F-LSSVM) classifier. The hyper-parameters and kernel of classifier are selected such that the accuracy of each subband is maximized using GWO algorithm.

Results: The effectiveness and superiority of the proposed method is tested by evaluating seven performance parameters. An accuracy of 91.39%, sensitivity, specificity, precision, F-1 measure, false positive rate and error of 92.65%, 93.22%, 95.57%, 0.9306, 6.78% and 8.61% is achieved. The results prove superiority of the developed F-TQWT decomposition and F-LSSVM classifier over existing methodologies.

Conclusion: The EEG signals of healthy control and SZ subjects performing motor and auditory tasks simultaneously provide higher discrimination ability over the subjects performing auditory and motory tasks separately. The developed model is accurate, robust, and effective as it is developed on a relatively larger data-set, obtained maximum performance, and tested using ten-fold cross-validation technique. This proposed model is ready to be put to test for real-time SZ detection.

Keywords: Channel selection; Electroencephalogram signals; Flexible least square support vector machine classifier; Flexible tunable Q wavelet transform; Schizophrenia detection.