Objective: Using Meta-analysis to evaluate the relation of sugar-sweetened beverages (SSBs) intakes and artificially sweetened beverages (ASBs) intakes with risk of incident cardiovascular disease. Methods: "Sugar-sweetened beverages"(SSBs),"artificially sweetened beverages"(ASBs),"coronary heart disease"(CHD),"stroke","cardiovascular disease"(CVD), and related terms (both in English and in Chinese) were searched in Pubmed, EMBASE, Web of Science, Cochrane library, ProQuest, China National Knowledge Infrastructure (CNKI), Wanfang databases, and VIP Chinese Science and Technology Journal. Besides, it searched for additional references in websites including Clinical Tirals.gov and International Clinical Trials Registry Platform. The time was up to May 31st 2020. Stata 13 software was used to calculate pooled RR, perform heterogeneity test, and assess publication bias. Results: A total of 14 articles were included from the 40 804 articles retrieved, including 12 articles from European and American countries and 2 articles from Asian countries. The baseline mean age of the participants ranged from 52 to 69 years, and the mean follow-up time was from 6 to 26 years. Meta-analysis showed that compared with those in the lowest group, the RR (95%CI) for those in the highest group of SSBs consumption was 1.11 (1.04-1.08) for CHD, 1.10 (1.01-1.19) for stroke, and 1.09 (0.96-1.24) for CVD events. The corresponding RR (95%CI) comparing extreme groups of ASBs consumption was 1.10 (0.98-1.23) for CHD, 1.19 (1.09-1.29) for stroke, and 1.32 (1.15-1.52) for CVD events. Further analysis for subtypes of stroke showed that compared with the lowest group, the RR (95%CI) for those in the highest groups of SSBs consumption was 1.10 (0.99-1.22) for ischemic stroke and 0.86 (0.71-1.04) for hemorrhagic stroke. The corresponding RR (95%CI) comparing extreme consumption of ASBs was 1.23 (1.04-1.46) for ischemic stroke and 1.33 (1.03-1.72) for hemorrhagic stroke. Conclusion: Higher consumption of SSBs or ASBs may lead to increased risk of incident CHD and stroke (particularly ischemic stroke).
目的： 采用Meta分析探讨含糖饮料及人工甜味剂饮料摄入与人群新发心血管疾病的关联。 方法： 以sugar-sweetened beverages、artificially sweetened beverages、coronary heart disease、stroke、cardiovascular disease、含糖饮料、人工甜味剂饮料、冠心病、卒中、脑卒中、脑出血、心血管疾病为关键词，系统检索PubMed、EMBASE、Web of Science、Cochrane library、ProQuest、中国知网、万方数据服务平台、维普中文科技期刊等数据库截至2020年5月31日发表的饮料摄入与新发心血管疾病关联的相关文献，同时从ClinicalTirals.gov、International Clinical Trials Registry Platform网站补充收集相关文献。采用Stata 13软件分析数据，计算合并的RR（95%CI）值、检验异质性、评估发表偏倚。 结果： 从检索的40 804篇文献中，最终纳入14篇文献，其中12篇来自欧美国家，2篇来自亚洲国家。研究对象的基线平均年龄为52~69岁，平均随访时间为6~26年。Meta分析结果显示，与最低组相比，合并的含糖饮料摄入量最高者冠心病、卒中和心血管事件的发病风险RR（95%CI）值分别为1.11（1.04~1.18）、1.10（1.01~1.19）及1.09（0.96~1.24）；合并的人工甜味剂摄入量最高者冠心病、卒中和心血管事件的发病风险RR（95%CI）值分别为1.10（0.98~1.23）、1.19（1.09~1.29）、1.32（1.15~1.52）。对于卒中亚型进一步分析发现，与最低组相比，合并的含糖饮料摄入量最高者缺血性脑卒中、出血性脑卒中的发病RR（95%CI）值分别为1.10（0.99~1.22）、0.86（0.71~1.04）；合并的人工甜味剂摄入量最高者缺血性脑卒中、出血性脑卒中的发病RR（95%CI）值分别为1.23（1.04~1.46）、1.33（1.03~1.72）。 结论： 摄入过多含糖饮料或人工甜味剂饮料可能增加人群冠心病及卒中，尤其是缺血性脑卒中的发病风险。.