[Chinese expert consensus on keratoprosthesis procedure (2021)]

Zhonghua Yan Ke Za Zhi. 2021 Oct 11;57(10):727-733. doi: 10.3760/cma.j.cn112142-20210713-00333.
[Article in Chinese]

Abstract

An artificial corneal transplant (keratoprosthesis, KPro) is the only procedure to restore sight for patients with end-stage corneal blindness after multiple failed corneal transplants, severe eye burns, autoimmune-related and cicatricial keratoconjunctival diseases. At present, the representative KPros are Boston KPros and Russian MICOF KPros. They have been used for patients worldwide for nearly 30 years, and the success rate in two years after surgery reaches up to 85%. With the approval of the collar button design KPro (Boston Ⅰ-like artificial cornea) for marketing and the completion of clinical trials of the Miok KPro (MICOF-like artificial cornea) in China, domestic artificial corneas will bring Chinese patients with end-stage corneal blindness opportunities for recovery of eyesight. There are many differences between the KPro procedure and conventional corneal transplantation. In order to standardize the use of domestic KPros in clinical practice and reduce perioperative complications, the Cornea Group of Ophthalmoloy Branch of Chinese Medical Association convened meetings of experts with extensive experience in this field, and a consensus has been reached on the surgical indications, operating specifications, perioperative medication and complication management targeting domestic KPro procedure to guide the performance of artificial corneal transplantation in China. (Chin J Ophthalmol, 2021, 57: 727-733).

人工角膜移植手术是多次角膜移植失败、严重眼烧伤(化学烧伤、热烧伤)、自身免疫相关性及瘢痕性角结膜疾病等终末期角膜盲患者复明的唯一方法。目前代表性产品有美国波士顿(Boston)人工角膜和俄罗斯Micof人工角膜,相关手术已在全球开展近30年,术后2年的成功率高达85%以上。随着我国领扣型人工角膜(仿Boston Ⅰ型人工角膜)批准上市和米赫人工角膜(仿Micof人工角膜)完成临床试验,国产人工角膜将给我国终末期角膜盲患者带来复明机会。人工角膜移植手术与常规角膜移植手术有诸多不同,为了使国产人工角膜在临床得到规范使用,减少手术并发症,中华医学会眼科学分会角膜病学组汇集该领域专家,在国产人工角膜移植手术的适应证、操作规范、围手术期用药及并发症处理等方面形成共识意见,为我国规范开展人工角膜移植手术提供指导。(中华眼科杂志,2021,57:727-733).

MeSH terms

  • China
  • Consensus
  • Cornea* / surgery
  • Corneal Diseases* / surgery
  • Humans
  • Prostheses and Implants