The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis

J Periodontol. 1986 Aug;57(8):472-9. doi: 10.1902/jop.1986.57.8.472.


A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / blood
  • Ascorbic Acid / pharmacology*
  • Chemotaxis, Leukocyte / drug effects*
  • Double-Blind Method
  • Female
  • Gingivitis / physiopathology*
  • Humans
  • Male
  • Neutrophils
  • Periodontal Diseases / prevention & control
  • Periodontal Index
  • Time Factors


  • Ascorbic Acid