Multipotent stromal cells: One name, multiple identities

Cell Stem Cell. 2021 Oct 7;28(10):1690-1707. doi: 10.1016/j.stem.2021.09.001.


Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and regeneration of most tissues. They can differentiate along multiple connective lineages, but unlike most other stem/progenitor cells, they carry out various other functions while maintaining their developmental potential. MSCs function as damage sensors, respond to injury by fostering regeneration through secretion of trophic factors as well as extracellular matrix (ECM) molecules, and contribute to fibrotic reparative processes when regeneration fails. Tissue-specific MSC identity, fate(s), and function(s) are being resolved through fate mapping coupled with single cell "omics," providing unparalleled insights into the secret lives of tissue-resident MSCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation
  • Extracellular Matrix
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells*
  • Multipotent Stem Cells
  • Stromal Cells