The current understanding of the benefits, safety, and regulation of cannabidiol in consumer products

Food Chem Toxicol. 2021 Nov:157:112600. doi: 10.1016/j.fct.2021.112600. Epub 2021 Oct 6.


The popularity of cannabidiol (CBD) in consumer products is soaring as consumers are using CBD for general health and well-being as well as to seek relief from ailments especially pain, inflammation, anxiety, depression, and sleep disorders. However, there are limited data currently in the public domain that provide support for these benefits. By contrast, a significant amount of safety evaluation data for CBD have been obtained recently from pre-clinical and clinical studies of the CBD therapeutic Epidiolex®. Yet some key data gaps concerning the safe use of CBD still remain. Furthermore, current regulations on CBD use in consumer products remain uncertain and often conflict between the state and federal level. In light of the rapidly expanding popularity of CBD-related products in the marketplace, here we review the current understanding of the benefits, safety, and regulations surrounding CBD in consumer products. This review does not advocate for or against the use of CBD in consumer products. Rather this review seeks to assess the state-of-the-science on the health effects and safety of CBD, to identify critical knowledge gaps for future studies, and to raise the awareness of the current regulations that govern CBD use in consumer products.

Keywords: CBD regulations; Cannabidiol; Cannabinoid; Consumer products; Hemp; Ingredient safety.

Publication types

  • Review

MeSH terms

  • Cannabidiol / adverse effects
  • Cannabidiol / therapeutic use*
  • Consumer Product Safety*
  • Drug and Narcotic Control*
  • Humans


  • Cannabidiol