Antitumor effects of L6, an IgG2a antibody that reacts with most human carcinomas

Proc Natl Acad Sci U S A. 1986 Sep;83(18):7059-63. doi: 10.1073/pnas.83.18.7059.

Abstract

Mouse monoclonal antibody L6 (IgG2a subtype) recognizes a ganglioside antigen expressed at the surface of cells from human non-small-cell lung carcinomas, breast carcinomas, and colon carcinomas. We now show that this antibody can lyse L6 antigen-positive human tumor cells in the presence of Leu-11b-positive human lymphocytes (i.e., mediate antibody-dependent cellular cytotoxicity) or human serum (mediate complement-dependent cytotoxicity) and that it can inhibit the outgrowth of an L6 antigen-positive human tumor transplanted onto nude mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Neoplasm / immunology*
  • Antibody-Dependent Cell Cytotoxicity
  • Antigens, Neoplasm / analysis
  • Complement System Proteins / immunology
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasms / immunology*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Immunoglobulin G
  • Complement System Proteins