[Research Progress of Non-coding RNA in Multiple Myeloma with Heart Disease---Review]

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Oct;29(5):1680-1684. doi: 10.19746/j.cnki.issn.1009-2137.2021.05.051.
[Article in Chinese]

Abstract

Some non-coding RNAs (ncRNA), as functional RNA molecules, lack potential to encode proteins, but can affect gene expression and disease progression through a variety of mechanisms. In multiple myeloma (MM), cardiovascular disease is one of the most common complications, which may be related to a variety of factors, including patient's own factors, disease-related factors, drug factors, etc. Non-coding RNA is considered to be an important regulator of cardiovascular event risk factors and cell function, and an important candidate target for improving the condition and prognostic assessment. This article briefly summarized the role of non-coding RNA in cardiac amyloidosis caused by MM, damage to the heart by inflammatory factors, and heart disease caused by chemotherapy drugs in recent years.

题目: 非编码RNA在多发性骨髓瘤伴有心脏病变中的研究进展.

摘要: 部分非编码RNA作为功能性RNA分子,虽然缺乏编码蛋白质的潜力,但可以通过多种机制影响基因的表达和疾病的进展。在多发性骨髓瘤中,心血管疾病是最常见的合并症之一,其可能与患者自身相关,也与疾病本身、药物治疗等有关。非编码RNA被认为是心血管事件危险因素和细胞功能的重要调节因子,是改善病情和预后评估的重要候选靶标。本文就近年来在多发性骨髓瘤导致的心脏淀粉样变性、炎性因子对心脏的损害和化疗药物导致的心脏病变中,非编码RNA发挥的作用作一综述。.

MeSH terms

  • Cardiovascular Diseases*
  • Heart Diseases*
  • Humans
  • Multiple Myeloma* / genetics
  • Prognosis
  • RNA, Untranslated / genetics

Substances

  • RNA, Untranslated