Heart failure in diabetes

Metabolism. 2021 Dec:125:154910. doi: 10.1016/j.metabol.2021.154910. Epub 2021 Oct 8.


Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.

Keywords: Adrenergic receptors; Aging; BHB; Bioenergetics; Cardiomyocytes; Cardiovascular endocrinology; Diabetes mellitus; Diabetic cardiomyopathy; Diastolic dysfunction; Endothelium; FOXO1; Fibroblasts; Fibrosis; HFpEF; Heart failure; Mitochondria; NADH; Oxidative stress; ROS; Senescence; T1DM; T2DM; VSMC.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Cardiomyopathies / etiology
  • Diabetic Cardiomyopathies / physiopathology*
  • Heart Failure / etiology
  • Heart Failure / physiopathology*
  • Humans