Inhibition of bone resorption in culture by (+)-catechin

Biochem Pharmacol. 1986 Sep 15;35(18):3091-4. doi: 10.1016/0006-2952(86)90391-6.

Abstract

A pretreatment with (+)-catechin renders embryonic mouse calvaria in culture resistant to the action of bone resorbing agents, either parathyroid hormone (PTH), prostaglandin E2 or retinoic acid, and inhibits in a parallel way the enhanced excretion of N-acetyl-beta-glucosaminidase, a reference lysosomal enzyme, induced by these agents; it has, however, no effect on the small spontaneous leakage of lactate dehydrogenase from the explants. Moreover, the resorption induced in calvaria by a pretreatment with PTH or retinoic acid is inhibited by a further culture with catechin. This inhibition of bone resorption is discussed in relation with the collagen-stabilizing properties of (+)-catechin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzopyrans / pharmacology*
  • Bone Resorption / drug effects*
  • Calcium / metabolism
  • Catechin / pharmacology*
  • Dinoprostone
  • Isoenzymes
  • L-Lactate Dehydrogenase / metabolism
  • Mice
  • Organ Culture Techniques
  • Parathyroid Hormone / pharmacology
  • Prostaglandins E / pharmacology
  • Tretinoin / pharmacology

Substances

  • Benzopyrans
  • Isoenzymes
  • Parathyroid Hormone
  • Prostaglandins E
  • Tretinoin
  • Catechin
  • L-Lactate Dehydrogenase
  • Dinoprostone
  • Calcium