Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis

Trends Cell Biol. 2022 Mar;32(3):182-185. doi: 10.1016/j.tcb.2021.09.004. Epub 2021 Oct 8.

Abstract

Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots of native large ribosomal subunit intermediates into the complex pathway of mitochondrial ribosome assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalytic Domain
  • Humans
  • Mitochondrial Ribosomes* / chemistry
  • Mitochondrial Ribosomes* / metabolism
  • Organelle Biogenesis
  • RNA, Ribosomal / metabolism
  • Ribosomal Proteins / analysis
  • Ribosomal Proteins / genetics
  • Ribosomal Proteins / metabolism
  • Ribosomes* / metabolism

Substances

  • RNA, Ribosomal
  • Ribosomal Proteins