Co(III)-catalysed regioselective linear C(8)-H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

Devesh Chandra; Nikunj Kumar; Sumit; Diksha Parmar; Puneet Gupta; Upendra Sharma

doi:10.1039/d1cc04541e

Co(III)-catalysed regioselective linear C(8)-H olefination of isoquinolone with terminal aromatic and aliphatic alkynes

Chem Commun (Camb). 2021 Nov 4;57(88):11613-11616. doi: 10.1039/d1cc04541e.

Authors

Devesh Chandra^{1

2}, Nikunj Kumar³, Sumit^{1

2}, Diksha Parmar^{1

2}, Puneet Gupta³, Upendra Sharma^{1

2}

Affiliations

¹ Chemical Technology Division, CSIR-IHBT, Palampur, HP 176 061, India. upendraihbt@gmail.com.
² Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
³ Computational Catalysis Center, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India. puneet.gupta@cy.iitr.ac.in.

PMID: 34636826
DOI: 10.1039/d1cc04541e

Abstract

A regioselective C8 linear olefination of isoquinoline-1H-2-one with terminal (aromatic and aliphatic) alkynes is reported under Co(III) catalysis. This is an exclusive report on the C8 functionalization of isoquinolone using non-noble transition metal complexes. Experimental and computational mechanistic studies have also been performed to depict the reaction pathway.