Study on the Physical Properties of a SiNW Biosensor to the Sensitivity of DNA Detection

Materials (Basel). 2021 Sep 30;14(19):5716. doi: 10.3390/ma14195716.


SiNW (silicon nanowire) arrays consisting of 5- and 10-wires were fabricated by using an atomic force microscope-the local anodic oxidation (AFM-LAO) technique followed by wet chemical etching. Tetramethylammonium hydroxide (TMAH) and isopropyl alcohol (IPA) at various concentrations were used to etch SiNWs. The SiNWs produced were differed in dimension and surface roughness. The SiNWs were functionalized and used for the detection of deoxyribonucleic acid (DNA) dengue (DEN-1). SiNW-based biosensors show sensitive detection of dengue DNA due to certain factors. The physical properties of SiNWs, such as the number of wires, the dimensions of wires, and surface roughness, were found to influence the sensitivity of the biosensor device. The SiNW biosensor device with 10 wires, a larger surface-to-volume ratio, and a rough surface is the most sensitive device, with a 1.93 fM limit of detection (LOD).

Keywords: dengue biosensor; dimension; number of wires; sensitivity; silicon nanowires; surface roughness.