Subacute thyroiditis after vaccination against SARS-CoV-2

Tidsskr Nor Laegeforen. 2021 Oct 11;141(2021-14). doi: 10.4045/tidsskr.21.0554. Print 2021 Oct 12.
[Article in English, Norwegian]


Background: Subacute thyroiditis is a clinical condition usually seen 1-2 weeks after a viral infection in the upper respiratory tract, and has also been reported following infection with COVID-19. Cases of subacute thyroiditis following a seasonal influenza vaccination have been described, and recent case reports have reported clinical symptoms and signs typical of subacute thyroiditis following vaccination with mRNA SARS-CoV-2 vaccine.

Case presentation: A young, healthy female underwent surgery with left-side lobectomy for papillary thyroid carcinoma. Hashimoto's thyroiditis was revealed as an additional histological finding. Six days prior to complementary thyroidectomy of the right lobe the patient received mRNA SARS-CoV-2 vaccine. The histological slides showed features consistent with extensive subacute thyroiditis throughout the entire lobe.

Interpretation: As no other aetiology could account for the subacute thyroiditis, the vaccination against COVID-19 is seen as a plausible source.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • Female
  • Humans
  • SARS-CoV-2
  • Thyroid Neoplasms*
  • Thyroiditis, Subacute* / etiology
  • Vaccination / adverse effects


  • COVID-19 Vaccines