Dissolving the cytosolic bacteria in non-immune cells

Fengjiao Lu; Xuetao Cao

doi:10.1016/j.it.2021.09.010

Dissolving the cytosolic bacteria in non-immune cells

Trends Immunol. 2021 Nov;42(11):943-944. doi: 10.1016/j.it.2021.09.010. Epub 2021 Oct 9.

Authors

Fengjiao Lu¹, Xuetao Cao²

Affiliations

¹ Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.
² Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China. Electronic address: caoxt@immunol.org.

PMID: 34642092
DOI: 10.1016/j.it.2021.09.010

Abstract

How do mammalian non-immune cells manage to control intracellular pathogens? With a genome-wide CRISPR-Cas9 screen, Gaudet et al. identified apolipoprotein L3 (APOL3), induced by IFN-γ, as a crucial host factor targeting and killing intracellular bacteria and thus revealing a new IFN-γ-dependent innate defense mechanism in non-immune cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacteria*
Humans
Immunity, Innate*
Mammals