A total of 106 patients with squamous cell carcinoma of the oral cavity and maxillary sinus in Nigerians were studied and analysed clinicopathologically for sex, age, site distribution as well as histological differentiation. The lesion was commoner in males than females (ratio 1.3 to 1.0) and was recorded in the age range 14 to 80 years. The mean age at presentation was 49 +/- 15.2 years, median age 49.5 years and a mode value at 51-60 years. The mandibular gingiva was the commonest anatomical site for the lesion, accounting for 28.6% of the total. Almost half of the cases (47.2%) presented histologically as well differentiated squamous cell carcinoma. Poorly differentiated squamous cell carcinoma was seen at a lower mean age 43 +/- 16 years when compared to other histological types.