Treatment with ibrutinib does not induce a TP53 clonal evolution in chronic lymphocytic leukemia

Luciana Cafforio; Sara Raponi; Luca Vincenzo Cappelli; Caterina Ilari; Roberta Soscia; Maria Stefania De Propris; Paola Mariglia; Gian Matteo Rigolin; Antonella Bardi; Nadia Peragine; Alfonso Piciocchi; Valentina Arena; Francesca Romana Mauro; Antonio Cuneo; Anna Guarini; Robin Foa; Ilaria Del Giudice

doi:10.3324/haematol.2020.263715

Treatment with ibrutinib does not induce a TP53 clonal evolution in chronic lymphocytic leukemia

Haematologica. 2022 Jan 1;107(1):334-337. doi: 10.3324/haematol.2020.263715.

Authors

Luciana Cafforio¹, Sara Raponi¹, Luca Vincenzo Cappelli¹, Caterina Ilari¹, Roberta Soscia¹, Maria Stefania De Propris¹, Paola Mariglia¹, Gian Matteo Rigolin², Antonella Bardi², Nadia Peragine¹, Alfonso Piciocchi³, Valentina Arena³, Francesca Romana Mauro¹, Antonio Cuneo², Anna Guarini⁴, Robin Foa¹, Ilaria Del Giudice⁵

Affiliations

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University.
² Hematology Section, Department of Medical Science, Azienda Ospedaliero-Universitaria Arcispedale S. Anna, University of Ferrara.
³ GIMEMA Data Center, GIMEMA Foundation.
⁴ Department of Molecular Medicine, Sapienza University, Rome.
⁵ Hematology, Department of Translational and Precision Medicine, Sapienza University. delgiudice@bce.uniroma1.it.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Clonal Evolution / genetics
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Piperidines
Tumor Suppressor Protein p53 / genetics

Substances

Piperidines
TP53 protein, human
Tumor Suppressor Protein p53
ibrutinib
Adenine

Grants and funding

Funding: the authors wish to thank the Associazione Italiana per la Ricerca sul Cancro (AIRC), Metastases Special Program, N° 21198, Milan, Italy (RF); Progetti di Rilevante Interesse Nazionale (PRIN) 2015ZMRFEA (RF, AC).