Brain development in premature infants: A bug in the programming system?

Gerard Clarke; Anna Aatsinki; Siobhain M O'Mahony

doi:10.1016/j.chom.2021.09.015

Brain development in premature infants: A bug in the programming system?

Cell Host Microbe. 2021 Oct 13;29(10):1477-1479. doi: 10.1016/j.chom.2021.09.015.

Authors

Gerard Clarke¹, Anna Aatsinki², Siobhain M O'Mahony³

Affiliations

¹ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland. Electronic address: g.clarke@ucc.ie.
² APC Microbiome Ireland, University College Cork, Cork, Ireland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Finland.
³ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.

PMID: 34648739
DOI: 10.1016/j.chom.2021.09.015

Abstract

In this issue of Cell Host & Microbe, Seki et al. (2021) demonstrate an overgrowth of Klebsiella in the gut microbiota of extremely premature infants that is predictive of brain damage. The Klebsiella-associated pro-inflammatory signature suggests that aberrant microbiome-gut-brain axis signaling provokes the disruption of neurodevelopmental trajectories to exacerbate brain injury.

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MeSH terms

Brain
Brain-Gut Axis*
Gastrointestinal Microbiome*
Humans
Infant, Newborn
Infant, Premature
Signal Transduction