Resveratrol (RV): A pharmacological review and call for further research

Biomed Pharmacother. 2021 Nov;143:112164. doi: 10.1016/j.biopha.2021.112164. Epub 2021 Oct 2.

Abstract

Resveratrol (RV) is a well-known polyphenolic compound in various plants, including grape, peanut, and berry fruits, which is quite famous for its association with several health benefits such as anti-obesity, cardioprotective neuroprotective, antitumor, antidiabetic, antioxidants, anti-age effects, and glucose metabolism. Significantly, promising therapeutic properties have been reported in various cancer, neurodegeneration, and atherosclerosis and are regulated by several synergistic pathways that control oxidative stress, cell death, and inflammation. Similarly, RV possesses a strong anti-adipogenic effect by inhibiting fat accumulation processes and activating oxidative and lipolytic pathways, exhibiting their cardioprotective effects by inhibiting platelet aggregation. The RV also shows significant antibacterial effects against various food-borne pathogens (Listeria, Campylobacter, Staphylococcus aureus, and E. coli) by inhibiting an electron transport chain (ETC) and F0F1-ATPase, which decreases the production of cellular energy that leads to the spread of pathogens. After collecting and analyzing scientific literature, it may be concluded that RV is well tolerated and favorably affects cardiovascular, neurological, and diabetic disorders. As such, it is possible that RV can be considered the best nutritional additive and a complementary drug, especially a therapeutic candidate. Therefore, this review would increase knowledge about the blend of RV as well as inspire researchers around the world to consider RV as a pharmaceutical drug to combat future health crises against various inhumane diseases. In the future, this article will be aware of discoveries about the potential of this promising natural compound as the best nutraceuticals and therapeutic drugs in medicine.

Keywords: Anti-aging; Anti-cancer; Antimicrobial; Antioxidant; Cardiovascular disorders; Immunomodulatory; Metabolic disorders; Neurodegenerative disease; Nutraceuticals; Pharmacological activity; Reproductive system; Respiratory system; Resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Dietary Supplements* / adverse effects
  • Humans
  • Patient Safety
  • Phytochemicals / adverse effects
  • Phytochemicals / pharmacokinetics
  • Phytochemicals / therapeutic use*
  • Resveratrol / adverse effects
  • Resveratrol / pharmacokinetics
  • Resveratrol / therapeutic use*
  • Risk Assessment

Substances

  • Phytochemicals
  • Resveratrol