Reviving through human hippocampal newborn neurons

Encephale. 2022 Apr;48(2):179-187. doi: 10.1016/j.encep.2021.09.001. Epub 2021 Oct 11.


Recent contradictory data has renewed discussion regarding the existence of adult hippocampal neurogenesis (AHN) in humans, i.e., the continued production of new neurons in the brain after birth. The present review revisits the debate of AHN in humans from a historical point of view in the face of contradictory evidence, analyzing the methods employed to investigate this phenomenon. Thus, to date, of the 57 studies performed in humans that we reviewed, 84% (48) concluded in favor of the presence of newborn neurons in the human adult hippocampus. Besides quality of the tissue (such as postmortem intervals below 26hours as well as tissue conservation and fixation), considerations for assessing and quantify AHN in the human brain require the use of stereology and toxicological analyses of clinical data of the patient.

Keywords: Adult hippocampal neurogenesis in humans; Controversy; Neuron.

Publication types

  • Review

MeSH terms

  • Adult
  • Hippocampus* / physiology
  • Humans
  • Infant, Newborn
  • Neurogenesis* / physiology
  • Neurons / physiology