Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex

Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702. doi: 10.1073/pnas.83.22.8699.

Abstract

The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Deletion
  • Chromosome Mapping
  • DNA / analysis
  • Glycoproteins / genetics*
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Humans
  • Major Histocompatibility Complex*
  • Tumor Necrosis Factor-alpha

Substances

  • Glycoproteins
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Tumor Necrosis Factor-alpha
  • DNA