Frequency of Hypoglycemia in Children With Adrenal Insufficiency

Acta Endocrinol Suppl (Copenh). 1986;279:275-8. doi: 10.1530/acta.0.112s275.

Abstract

The frequency of hypoglycemia in 165 children with primary adrenal insufficiency, 118 of whom had Congenital Adrenal Hyperplasia and 47 Addison's Disease, was 18%. Half of the hypoglycemic episodes occurred in the neonatal period. Hypoglycemia was isolated in 13 children, revealing the disease in 4 newborns with Congenital Adrenal Hypoplasia and in a boy with 11 B Hydroxylase deficiency. Basal plasma cortisol levels were significantly lower in those of subjects who experienced hypoglycemia (47.1 +/- 28.6 ng/ml vs. 106.0 +/- 86.6 ng/ml, p less than 0.001). A significant correlation (p less than 0.001) was found between the plasma concentration of glucose and cortisol at time of hypoglycemia.

MeSH terms

  • Addison Disease / complications
  • Adolescent
  • Adrenal Hyperplasia, Congenital / complications
  • Adrenal Insufficiency / blood
  • Adrenal Insufficiency / complications*
  • Child
  • Child, Preschool
  • Humans
  • Hydrocortisone / blood
  • Hypoglycemia / etiology*
  • Infant
  • Infant, Newborn

Substances

  • Hydrocortisone