Hydrogen-bonded silicene nanosheets of engineered bandgap and selective degradability for photodynamic therapy

Deliang Xu; Han Lin; Wujie Qiu; Min Ge; Zhixin Chen; Chenyao Wu; Yanling You; Xiangyu Lu; Chenyang Wei; Jianjun Liu; Xiang Guo; Jianlin Shi

doi:10.1016/j.biomaterials.2021.121172

Hydrogen-bonded silicene nanosheets of engineered bandgap and selective degradability for photodynamic therapy

Biomaterials. 2021 Nov:278:121172. doi: 10.1016/j.biomaterials.2021.121172. Epub 2021 Oct 4.

Authors

Deliang Xu¹, Han Lin², Wujie Qiu³, Min Ge³, Zhixin Chen³, Chenyao Wu³, Yanling You³, Xiangyu Lu³, Chenyang Wei³, Jianjun Liu³, Xiang Guo⁴, Jianlin Shi⁵

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
² State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China. Electronic address: linhan@mail.sic.ac.cn.
³ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
⁴ Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, PR China. Electronic address: gx9601074@smmu.edu.cn.
⁵ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China. Electronic address: jlshi@mail.sic.ac.cn.

PMID: 34653935
DOI: 10.1016/j.biomaterials.2021.121172

Abstract

Silicon, a highly biocompatible and ubiquitous chemical element in living systems, exhibits great potentials in biomedical applications. However, the silicon-based nanomaterials such as silica and porous silicon have been largely limited to only serving as carriers for delivery systems, due to the lack of intrinsic functionalities of silicon. This work presents the facile construction of a two-dimensional (2D) hydrogen-bonded silicene (H-silicene) nanosystem which is highlighted with tunable bandgap and selective degradability for tumor-specific photodynamic therapy facilely by surface covalent modification of hydrogen atoms. Briefly, the H-silicene nanosheet material is selectively degradable in normal neutral tissues but rather stable in the mildly acidic tumor microenvironment (TME) for achieving efficient photodynamic therapy (PDT). Such a 2D hydrogen-bonded silicene nanosystem featuring the tunable bandgap and tumor-selective degradability provides a new paradigm for the application of multi-functional two-dimensional silicon-based biomaterials towards the diagnosis and treatments of cancer and other diseases.

Keywords: Bandgap engineering; Degradability; Hydrogenation; Photodynamic therapy; Silicene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hydrogen
Neoplasms* / drug therapy
Photochemotherapy*
Silicon
Tumor Microenvironment

Substances

Hydrogen
Silicon