Vitamin E supplementation in inflammatory skin diseases

Dermatol Ther. 2021 Nov;34(6):e15160. doi: 10.1111/dth.15160. Epub 2021 Oct 21.


Vitamin E is a powerful lipophilic antioxidant that protects membranes from lipid peroxidation, and consequently, oxidative damage. Oxidative stress plays a role in the development of neurodegenerative diseases. Vitamin E supplementation is recommended in patients with vitamin E deficiency due to fat malabsorption. The addition of vitamin E to the diet slows Alzheimer's disease progression and protects older patients against respiratory infections. Recent studies also point to the involvement of oxidative stress in the pathology of immune-mediated skin diseases, such as atopic dermatitis and psoriasis. We reviewed the available clinical trials that investigated the role of vitamin E supplementation in preventing and treating atopic dermatitis and psoriasis. Data from these studies point to a positive role of vitamin E supplementation in these diseases. Still, due to limitations in study design, further evidence is needed to reach a definite conclusion.

Keywords: Vitamin E; antioxidants; atopic dermatitis; oxidative stress; psoriasis; supplementation.

Publication types

  • Review

MeSH terms

  • Antioxidants / therapeutic use
  • Dermatitis, Atopic* / drug therapy
  • Dietary Supplements*
  • Humans
  • Lipid Peroxidation
  • Oxidative Stress
  • Vitamin E / therapeutic use


  • Antioxidants
  • Vitamin E