SARS-CoV-2 infection induced thyroid storm and heart failure in an adolescent girl

Cardiol Young. 2022 Jun;32(6):988-992. doi: 10.1017/S1047951121004352. Epub 2021 Oct 18.


We report a case of thyroid storm precipitated by SARS-CoV-2 infection in an adolescent girl with a history of Graves disease and dilated cardiomyopathy. This case highlights that SARS-CoV-2 infection can potentially trigger a thyrotoxicosis crisis and acute decompensated heart failure in a patient with underlying thyroid disease and myocardial dysfunction even in the absence of multi-system inflammatory syndrome in children. We systematically reviewed the thyrotoxicosis cases with SARS-CoV-2 infection and described its impact on pre-existing dilated cardiomyopathy.

Keywords: SARS-CoV-2 infection in children; dilated cardiomyopathy; graves disease; thyroid storm.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adolescent
  • COVID-19* / complications
  • Cardiomyopathy, Dilated*
  • Child
  • Female
  • Heart Failure* / etiology
  • Humans
  • SARS-CoV-2
  • Systemic Inflammatory Response Syndrome
  • Thyroid Crisis* / complications
  • Thyroid Crisis* / diagnosis
  • Thyrotoxicosis* / complications
  • Thyrotoxicosis* / diagnosis

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related