Non-coding RNAs in the Pathogenesis of Multiple Sclerosis

Aadil Yousuf; Abrar Qurashi

doi:10.3389/fgene.2021.717922

Non-coding RNAs in the Pathogenesis of Multiple Sclerosis

Front Genet. 2021 Sep 30:12:717922. doi: 10.3389/fgene.2021.717922. eCollection 2021.

Authors

Aadil Yousuf¹, Abrar Qurashi¹

Affiliation

¹ Department of Biotechnology, University of Kashmir, Srinagar, India.

Abstract

Multiple sclerosis (MS) is an early onset chronic neurological condition in adults characterized by inflammation, demyelination, gliosis, and axonal loss in the central nervous system. The pathological cause of MS is complex and includes both genetic and environmental factors. Non-protein-coding RNAs (ncRNAs), specifically miRNAs and lncRNAs, are important regulators of various biological processes. Over the past decade, many studies have investigated both miRNAs and lncRNAs in patients with MS. Since then, insightful knowledge has been gained in this field. Here, we review the role of miRNAs and lncRNAs in MS pathogenesis and discuss their implications for diagnosis and treatment.

Keywords: central nervous system; long noncoding RNA; microRNA; multiple sclerosis; neurodegeneration.

Publication types

Review