Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice

Micheli Zanetti; Mikaela Scatolin; Amanda Rebonatto Oltramari; Maria Luiza Lima da Costa Lopes; Rubieli Carla Frezza Zeferino; Gustavo Lopes Colpani; Liz Girardi Müller; Débora de Oliveira; Marcio Antônio Fiori

doi:10.1155/2021/3493625

Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice

Evid Based Complement Alternat Med. 2021 Oct 6:2021:3493625. doi: 10.1155/2021/3493625. eCollection 2021.

Affiliations

¹ Department of Chemical Engineering and Food Engineering, Community University of Chapecó Region (UNOCHAPECÓ), Chapecó 89809-000, SC, Brazil.
² Graduate Program in Technology and Management of the Innovation, Community University of Chapecó Region (UNOCHAPECÓ), Chapecó 89809 000, SC, Brazil.
³ Department of Pharmacy, Community University of Chapecó Region (UNOCHAPECÓ), Chapecó 89809-000, SC, Brazil.
⁴ Department of Veterinary Medicine, Community University of Chapecó Region (UNOCHAPECÓ), Chapecó 89809-000, SC, Brazil.
⁵ Graduate Program in Environmental Science, Community University of Chapecó Region (UNOCHAPECÓ), Chapecó 89809-000, SC, Brazil.
⁶ Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina (UFSC), Florianópolis 88040-900, SC, Brazil.

Abstract

In the present study, the antifungal activity and toxicity of the geranyl cinnamate ester (GCE) were investigated. The GCE showed antifungal activity at a minimum concentration of 0.16 μL/mL against Candida albicans and at concentrations greater than 2.5 μL/mL against Aspergillus niger. In acute toxicity studies, the administration of GCE (2.000 mg/kg) affected the body weight gain and food intake but did not induce the mortality of the animals studied. After the investigation of repeated-dose toxicity of GCE at 2 and 4 mg/kg, the hematological and biochemical parameters were changed. In addition, the adrenal weight of male mice treated with GCE at 4 mg/kg was affected. In conclusion, according to the Organization for Economic Cooperation and Development (OECD) acute toxicity parameters, the geranyl cinnamate ester can be classified into safety category number 5. The results of this study suggested that the geranyl cinnamate ester may be a source of natural antifungals.