Pediatric penicillin drug reactions may present in many forms such as erythema multiforme, serum-sickness, serum-sickness-like reaction (SSLR), Henoch-Schonlein Purpura (HSP), and urticarial vasculitis. Here, we review the case of a 13-month-old with atypical presentation of a drug reaction with increasing severity after each exposure to amoxicillin. We discuss the various differential diagnoses in comparison to our patient's presentation and conclude with the recommendation of considering timing and previous exposures in the diagnosis of drug-associated rashes in pediatric population.
Keywords: acute hemorrhagic edema of infancy; erythema multiforme; exanthematous drug eruption; henoch-shonlein purpura.; serum sickness-like reaction; urticaria multiforme; urticarial vasculitis.
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