Abstract
Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events seen in VITT.
MeSH terms
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Adenoviridae / genetics*
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Animals
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COVID-19 / complications
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COVID-19 / immunology
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COVID-19 / prevention & control
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COVID-19 Vaccines / adverse effects*
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COVID-19 Vaccines / genetics
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COVID-19 Vaccines / immunology*
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Humans
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Platelet Activation
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Platelet Factor 4 / immunology
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Thrombocytopenia* / etiology
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Thrombocytopenia* / immunology
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Thrombosis* / etiology
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Thrombosis* / immunology
Substances
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COVID-19 Vaccines
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Platelet Factor 4