Mitochondria and the Tumour Microenvironment in Blood Cancer

Jamie A Moore; Jayna J Mistry; Stuart A Rushworth

doi:10.1007/978-3-030-73119-9_10

Mitochondria and the Tumour Microenvironment in Blood Cancer

Adv Exp Med Biol. 2021:1329:181-203. doi: 10.1007/978-3-030-73119-9_10.

Authors

Jamie A Moore¹, Jayna J Mistry^{1

2}, Stuart A Rushworth³

Affiliations

¹ Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK.
² Earlham Institute, Norwich, UK.
³ Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK. s.rushworth@uea.ac.uk.

PMID: 34664240
DOI: 10.1007/978-3-030-73119-9_10

Abstract

The bone marrow (BM) is a complex organ located within the cavities of bones. The main function of the BM is to produce all the blood cells required for a normal healthy blood system. As with any major organ, many diseases can arise from errors in bone marrow function, including non-malignant disorders such as anaemia and malignant disorders such as leukaemias. This article will explore the role of the bone marrow, in normal and diseased haematopoiesis, with an emphasis on the requirement for intercellular mitochondrial transfer in leukaemia.

Keywords: Acute myeloid leukaemia; Bone marrow; CX43; Connexin channels; Extracellular vesicles; Haematopoiesis; Leukaemia; Mitochondrial; Mitochondrial transfer; Multiple myeloma; Stem cells; TNT; Tumour microenvironment; Tunnelling nanotubule.

MeSH terms

Bone Marrow / metabolism
Hematologic Neoplasms* / metabolism
Humans
Leukemia* / metabolism
Mitochondria
Tumor Microenvironment