Prognostic value of D-dimer/fibrinogen ratio on in-hospital outcomes of patients with heart failure and COVID-19

Biomark Med. 2021 Nov;15(16):1519-1528. doi: 10.2217/bmm-2021-0341. Epub 2021 Oct 20.

Abstract

Aim: In the present study, the relationship between D-dimer/fibrinogen ratio (DFR) and in-hospital outcomes was evaluated in patients with COVID-19 and a diagnosis of heart failure (HF). Materials & methods: In-hospital outcomes were compared in patients with high and low DFR values. Results: With regard to in-hospital outcomes, patients in the third tertile of DFR had a higher rate of mechanical ventilation, cardiogenic shock and death (p < 0.001). The length of ICU stay was longer in the third tertile group (p < 0.001). When evaluated together with infection markers, DFR was found to be an independent predictor of outcomes. Conclusion: DFR can be used as a prognostic marker in patients with COVID-19 with a diagnosis of HF, and perhaps more valuable than other infection markers.

Keywords: D-dimer/fibrinogen ratio; coronavirus disease; heart failure.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • COVID-19 / blood*
  • COVID-19 / diagnosis
  • COVID-19 / therapy
  • Female
  • Fibrin Fibrinogen Degradation Products / metabolism*
  • Fibrinogen / metabolism*
  • Heart Failure / blood*
  • Heart Failure / diagnosis
  • Heart Failure / therapy
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • SARS-CoV-2*

Substances

  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • Fibrinogen