One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Chem Commun (Camb). 2021 Nov 11;57(90):11948-11951. doi: 10.1039/d1cc04703e.

Abstract

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

MeSH terms

  • Animals
  • Antiviral Agents* / chemical synthesis
  • Antiviral Agents* / chemistry
  • Antiviral Agents* / pharmacology
  • Chlorocebus aethiops
  • Glycerol* / chemical synthesis
  • Glycerol* / chemistry
  • Glycerol* / pharmacology
  • Heparin* / chemical synthesis
  • Heparin* / chemistry
  • Heparin* / pharmacology
  • Herpesvirus 1, Human* / drug effects
  • Molecular Structure
  • Polymers* / chemical synthesis
  • Polymers* / chemistry
  • Polymers* / pharmacology
  • Vero Cells

Substances

  • Polymers
  • Antiviral Agents
  • Heparin
  • Glycerol
  • polyglycerol