Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

Chelsey ShengQi Zhao; Lei Yan; Wenqing He; Lee Cyn Ang; Qi Zhang

doi:10.1111/bpa.13030

Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

Brain Pathol. 2022 Mar;32(2):e13030. doi: 10.1111/bpa.13030. Epub 2021 Oct 20.

Authors

Chelsey ShengQi Zhao¹, Lei Yan¹, Wenqing He², Lee Cyn Ang^{1

3}, Qi Zhang^{1

3}

Affiliations

¹ Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
² Department of Statistical and Actuarial Sciences, Western University, London, Ontario, Canada.
³ Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.

Abstract

Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.

Keywords: claustrum; corticobasal degeneration; digital pathology; progressive supranuclear palsy; tauopathy.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Brain / pathology
Corticobasal Degeneration*
Humans
Supranuclear Palsy, Progressive* / diagnosis
Supranuclear Palsy, Progressive* / pathology
tau Proteins / metabolism

Substances

tau Proteins