Democratizing long-read genome assembly

Melanie Kirsche; Michael C Schatz

doi:10.1016/j.cels.2021.09.010

Democratizing long-read genome assembly

Cell Syst. 2021 Oct 20;12(10):945-947. doi: 10.1016/j.cels.2021.09.010.

Authors

Melanie Kirsche¹, Michael C Schatz²

Affiliations

¹ Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
² Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: mschatz@cs.jhu.edu.

PMID: 34672955
DOI: 10.1016/j.cels.2021.09.010

Abstract

De novo assembled genomes serve as the backbone for modern genomics. In an article in this issue of Cell Systems, Ekim et al. present the mdBG assembler that can assemble genomes 100-fold faster than previous methods, including a human genome in under 10 min, which unlocks pan-genomics for many species.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Genome, Human / genetics
Genomics*
High-Throughput Nucleotide Sequencing*
Humans
Sequence Analysis, DNA