The trafficking of protein aggregates through neural circuitries causes adverse outcomes, including propagation of pathology and toxicity in neurodegenerative diseases. In a recent issue of Cell, Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy in microglial networks that nurtures α-synuclein-loaded members back to health.
Keywords: microglia; mitochondria; neurodegenerative disorders; prion-like spreading; protein aggregation; α-synuclein.
Copyright © 2021. Published by Elsevier Inc.