Sharing is caring: The benefits of distributing protein aggregates among microglial networks

Neuron. 2021 Oct 20;109(20):3228-3230. doi: 10.1016/j.neuron.2021.10.008.


The trafficking of protein aggregates through neural circuitries causes adverse outcomes, including propagation of pathology and toxicity in neurodegenerative diseases. In a recent issue of Cell, Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy in microglial networks that nurtures α-synuclein-loaded members back to health.

Keywords: microglia; mitochondria; neurodegenerative disorders; prion-like spreading; protein aggregation; α-synuclein.

Publication types

  • Comment

MeSH terms

  • Humans
  • Microglia*
  • Neurodegenerative Diseases*
  • Protein Aggregates
  • alpha-Synuclein


  • Protein Aggregates
  • alpha-Synuclein