MiR-218 steps down to a threshold of motor impairment

Neuron. 2021 Oct 20;109(20):3233-3235. doi: 10.1016/j.neuron.2021.09.030.

Abstract

In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • 3' Untranslated Regions
  • Humans
  • MicroRNAs* / genetics
  • Motor Disorders*
  • Motor Neurons

Substances

  • 3' Untranslated Regions
  • MIRN218 microRNA, human
  • MicroRNAs