Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

Thorax. 2022 Apr;77(4):404-407. doi: 10.1136/thoraxjnl-2021-217870. Epub 2021 Oct 21.


Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

Keywords: occupational lung disease; paediatric interstitial lung disease; rare lung diseases; sarcoidosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Dust
  • Environmental Exposure / adverse effects
  • Humans
  • Occupational Exposure* / adverse effects
  • Occupations
  • Sarcoidosis*
  • Talc


  • Dust
  • Talc