Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications

Xueting Zhang; Wen Qi; Qi Xu; Xu Li; Liting Zhou; Lin Ye

doi:10.1007/s11356-021-17027-y

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications

Environ Sci Pollut Res Int. 2022 Jan;29(2):1634-1644. doi: 10.1007/s11356-021-17027-y. Epub 2021 Oct 22.

Authors

Xueting Zhang¹, Wen Qi¹, Qi Xu¹, Xu Li¹, Liting Zhou¹, Lin Ye²

Affiliations

¹ Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021, China.
² Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021, China. jlyelin@163.com.

PMID: 34677768
DOI: 10.1007/s11356-021-17027-y

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine disruptor. DEHP can be absorbed into the human body through the air, food, water, and skin. After entering the human body, DEHP is rapidly converted to mono(2-ethylhexyl) phthalate (MEHP) with greater toxicity than DEHP. An increasing number of studies indicates that DEHP or MEHP can damage the thyroid tissue and disrupt the function, but the mechanisms remain unclear. This article reviews the toxicity of DEHP on thyroid structures and functions and summarizes the potential mechanisms to provide evidence for preventing the thyroid-related diseases.

Keywords: DEHP; Estrogen receptor; Notch; Thyroid; Thyroid hormones.

Publication types

Review

MeSH terms

Diethylhexyl Phthalate* / toxicity
Endocrine Disruptors*
Humans
Phthalic Acids*
Thyroid Gland

Substances

Endocrine Disruptors
Phthalic Acids
phthalic acid
Diethylhexyl Phthalate

Abstract

Publication types

MeSH terms

Substances

Grants and funding