Nineteen of 26 cellular oncogenes precisely localized in the human genome map to one of the 83 bands involved in primary cancer-specific rearrangements

Hum Genet. 1987 Jan;75(1):70-2. doi: 10.1007/BF00273843.

Abstract

A total of 83 bands have been found to be specifically involved in primary structural chromosome rearrangements in human cancer. We have compared the distribution of these cancer-specific breakpoints with the chromosomal sites of the 26 cellular oncogenes currently mapped to individual bands within the human genome. Nineteen of the 26 oncogenes are localized in cancer-associated bands. This clustering of oncogene sites and cancer breakpoints is statistically highly significant (P = 0.0000012).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosome Mapping*
  • Genetic Markers*
  • Humans
  • Neoplasms / genetics*
  • Proto-Oncogenes*

Substances

  • Genetic Markers