Abstract
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.
Copyright © 2021 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aminopeptidases / chemistry
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Aminopeptidases / genetics
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Cerebellar Neoplasms* / drug therapy
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Cerebellar Neoplasms* / genetics
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Histocompatibility Antigens Class I / genetics
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Humans
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Medulloblastoma* / drug therapy
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Medulloblastoma* / genetics
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Minor Histocompatibility Antigens / genetics
Substances
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Histocompatibility Antigens Class I
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Minor Histocompatibility Antigens
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Aminopeptidases
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ERAP1 protein, human