Urinary Dickkopf-3 and kidney injury in patients with chronic pulmonary disease

Stefanie Thöni; Gert Mayer

doi:10.1016/j.kint.2021.08.012

Urinary Dickkopf-3 and kidney injury in patients with chronic pulmonary disease

Kidney Int. 2021 Nov;100(5):983-985. doi: 10.1016/j.kint.2021.08.012.

Authors

Stefanie Thöni¹, Gert Mayer²

Affiliations

¹ Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Tyrol, Austria.
² Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Tyrol, Austria. Electronic address: gert.mayer@i-med.ac.at.

PMID: 34688388
DOI: 10.1016/j.kint.2021.08.012

Abstract

Dickkopf-related protein 3 is a stress-induced, epithelial cell-derived glycoprotein that is promoted as a prognostic as well as a predictive urinary biomarker in acute and chronic kidney disease. Schunk et al. provided evidence that Dickkopf-related protein 3 identifies patients with chronic obstructive pulmonary disease and preserved kidney function at increased risk for a loss of estimated glomerular filtration rate and deterioration of pulmonary function. Experimental data highlighted Dickkopf-related protein 3-related pathophysiological similarities and interactions between chronic kidney disease and chronic obstructive pulmonary disease.

MeSH terms

Acute Kidney Injury* / diagnosis
Acute Kidney Injury* / etiology
Glomerular Filtration Rate
Humans
Kidney
Lung Diseases*
Renal Insufficiency, Chronic* / diagnosis