Y-190, a DNA probe for the sensitive detection of Y-derived marker chromosomes and mosaicism

Hum Genet. 1987 Feb;75(2):109-13. doi: 10.1007/BF00591069.

Abstract

A DNA probe (Y-190) is described that specifically hybridizes with repeated DNA sequences in the short arm of the human Y chromosome. The suitability of Y-190 to detect Y-derived DNA is shown in two patients with a 45,X/46,X+ marker karyotype and in a third patient previously described as having a 45,X karyotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA / genetics
  • Female
  • Genetic Markers*
  • Humans
  • Karyotyping
  • Male
  • Mosaicism*
  • Nucleic Acid Hybridization
  • Sex Chromosome Aberrations / diagnosis*
  • Sex Chromosome Aberrations / genetics
  • X Chromosome
  • Y Chromosome*

Substances

  • Genetic Markers
  • DNA