9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways

J Clin Invest. 1987 Mar;79(3):978-83. doi: 10.1172/JCI112909.


Prostaglandin (PG) D2, the predominant prostanoid released from activated mast cells in humans is initially metabolized by reduction of the C-11 keto function to yield 9 alpha,11 beta-PGF2. In this study the airways effects of 9 alpha,11 beta-PGF2 were compared with those of its epimer 9 alpha,11 alpha-PGF2 (PGF2 alpha) and PGD2. 9 alpha,11 beta-PGF2 was a potent contractile agonist of isolated guinea pig trachea and 4-mm human airways in vitro; the potencies of the PGs relative to PGD2 (= 1.00) being 0.65 (NS) and 4.08 (P less than 0.001) for 9 alpha,11 beta-PGF2, and 0.52 (P less than 0.01) and 2.40 (P less than 0.001) for PGF2 alpha, respectively. When inhaled by asthmatic subjects, 9 alpha,11 beta-PGF2 was a potent bronchoconstrictor agent, being approximately equipotent with PGD2 and 28-32 times more potent than histamine (P less than 0.01). These studies suggest that 9 alpha,11 beta-PGF2 is at least equipotent with PGD2 as a bronchoconstrictor agonist, and in being a major metabolite of PGD2, could contribute to the bronchoconstrictor effect of this mast cell-derived mediator in asthma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Airway Resistance / drug effects
  • Animals
  • Asthma / physiopathology
  • Bronchi / drug effects*
  • Bronchi / physiopathology
  • Dinoprost
  • Forced Expiratory Volume
  • Guinea Pigs
  • Histamine / pharmacology
  • Humans
  • Lung Volume Measurements
  • Male
  • Muscle Contraction / drug effects*
  • Prostaglandin D2
  • Prostaglandins D / pharmacology
  • Prostaglandins F / pharmacology*
  • Trachea / drug effects*
  • Trachea / physiology


  • Prostaglandins D
  • Prostaglandins F
  • Histamine
  • Dinoprost
  • Prostaglandin D2