Fusarium species are known to the dermatologist as cutaneous contaminants. Rarely they occur as pathogens. We report a case of disseminated Fusarium moniliforme in a 44-year-old patient with acute lymphocytic leukemia. We also review the previous reports of human Fusarium infections. The mycologic characteristics of Fusarium, including its nosologic and morphologic characteristics and its response to medications, are discussed.