Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions

Cureus. 2021 Sep 17;13(9):e18069. doi: 10.7759/cureus.18069. eCollection 2021 Sep.


Methotrexate, a folate antimetabolite and one of the first few anti-neoplastic drugs, is now a commonly used drug in the treatment of many inflammatory disorders ranging from diseases like rheumatoid arthritis to psoriasis. The life-threatening toxicity of methotrexate in inflammatory diseases is not commonly encountered. Here we report a case of life-threatening multiorgan failure from methotrexate toxicity, which was given for skin lesions suspected to be psoriasis.

Keywords: methotrexate; pancytopenia; psoriasis; septicemia; toxicity; ulcerative lesions.

Publication types

  • Case Reports