Pd-catalyzed allylative dearomatisation using Grignard reagents

Chem Commun (Camb). 2021 Nov 9;57(89):11807-11810. doi: 10.1039/d1cc05609c.


Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.