Plasma Glutathione and Prodromal Parkinson's Disease Probability

Sokratis Charisis; Eva Ntanasi; Maria Stamelou; Georgia Xiromerisiou; Maria Maraki; Aristidis S Veskoukis; Mary Yannakoulia; Mary H Kosmidis; Costas A Anastasiou; Nikolaos Giagkou; Efthimios Dardiotis; Georgios Hadjigeorgiou; Paraskevi Sakka; Demetrios Kouretas; Leonidas Stefanis; Nikolaos Scarmeas

doi:10.1002/mds.28826

Plasma Glutathione and Prodromal Parkinson's Disease Probability

Mov Disord. 2022 Jan;37(1):200-205. doi: 10.1002/mds.28826. Epub 2021 Oct 25.

Authors

Sokratis Charisis^{1

2}, Eva Ntanasi^{1

3}, Maria Stamelou^{4

5}, Georgia Xiromerisiou⁶, Maria Maraki^{7

8}, Aristidis S Veskoukis⁹, Mary Yannakoulia³, Mary H Kosmidis¹⁰, Costas A Anastasiou³, Nikolaos Giagkou^{1

4}, Efthimios Dardiotis⁶, Georgios Hadjigeorgiou¹¹, Paraskevi Sakka¹², Demetrios Kouretas¹³, Leonidas Stefanis^{1

14}, Nikolaos Scarmeas^{1

15}

Affiliations

¹ 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
² Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
³ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
⁴ Parkinson's Disease and Movement Disorders Department, HYGEIA Hospital, Athens, Greece.
⁵ Department of Neurology, Philipps University, Marburg, Germany.
⁶ School of Medicine, University of Thessaly, Larissa, Greece.
⁷ Section of Sport Medicine and Biology of Exercise, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.
⁸ Department of Nutrition and Dietetics, School of Health Sciences, Hellenic Mediterranean University, Crete, Greece.
⁹ Department of Nutrition and Dietetics, University of Thessaly, Trikala, Greece.
¹⁰ Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹¹ Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
¹² Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.
¹³ Department of Biochemistry-Biotechnology, University of Thessaly, Larisa, Greece.
¹⁴ Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
¹⁵ Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.

PMID: 34695238
DOI: 10.1002/mds.28826

Abstract

Background: A decrease in glutathione (GSH) levels is considered one of the earliest biochemical changes in Parkinson's disease (PD).

Objective: The authors explored the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD (pPD) by examining its longitudinal associations with pPD probability trajectories.

Methods: A total of 405 community-dwelling participants (median age [interquartile range] = 73.2 [7.41] years) without clinical features of parkinsonism were followed for a mean (standard deviation) of 3.0 (0.9) years.

Results: A 1 μmol/L increase in plasma GSH was associated with 0.4% (95% confidence interval [CI], 0.1%-0.7%; P = 0.017) less increase in pPD probability for 1 year of follow-up. Compared with participants in the lowest GSH tertile, participants in the highest GSH tertile had a 12.9% (95% CI, 22.4%-2.2%; P = 0.020) slower rate of increase of pPD probability for 1 year of follow-up.

Conclusion: Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. © 2021 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; oxidative stress; plasma glutathione; prodromal Parkinson's disease; redox biomarkers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Glutathione* / blood
Humans
Parkinson Disease* / blood
Parkinson Disease* / diagnosis
Probability
Prodromal Symptoms*

Substances

Glutathione