Immunosuppression and Kidney Transplantation

Abstract

Immunosuppression is complex, fraught with on-target and off-target adverse effects, and hard to get right but is the key to successful allotransplantation. Herein, we review the key immunosuppressive agent classes used for kidney transplant, highlighting mechanisms of action and typical clinical use.

Keywords: Antibody mediation rejection; Calcineurin inhibitors; Immunosuppression; Induction therapy; Kidney transplantation; Rejection; T-cell depleting agents; Transplant protocols.